Gold/Silica biochips: applications to Surface Plasmon Resonance and fluorescence quenching
نویسندگان
چکیده
We report Gold/Silica biochips for low cost biosensor devices. Firstly, the study of biochemical interactions on silica by means of Surface Plasmon Resonance (SPR) is presented. Secondly, Gold/Silica biochips are employed to reduce the strong quenching that occurs when a fluorophore is close to the gold surface. Furthermore, the control of the Silicalike thickness allows optimizing the distance between the metallic surface and the fluorophore in order to enhance the fluorescent signal. These results represent the first steps towards highly sensitive, specific and low cost biosensors based, for example, on Surface Plasmon Coupled Emission (SPCE) techniques. # To whom correspondence should be sent Tel.: +33 3 81 85 39 59 Fax: +33 3 81 85 39 98 email: [email protected] ha l-0 04 46 99 9, v er si on 1 13 J an 2 01 0 Author manuscript, published in "Laser Physics 19, 2 (2009) 252-58" DOI : 10.1134/S1054660X09020170
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تاریخ انتشار 2010